Backbone modification promotes peroxidase activity of G-quadruplex-based DNAzyme.
نویسندگان
چکیده
In this work we studied how backbone chemical modifications, such as 2'-O-methyl, phosphorothioate, L-form nucleotides and locked nucleic acid, on G-quadruplex based DNAzymes would affect their peroxidase activity. Our results indicate that 2'-O-methyl modification facilitates the formation of a perfectly compacted parallel structure and significantly promotes peroxidase activity of G-quadruplex based DNAzymes.
منابع مشابه
General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter
BACKGROUND A 39-base-pair sequence (Pu39WT) located 58 to 19 base pairs upstream of the Bcl-2 P1 promoter has been implicated in the formation of an intramolecular mixed G-quadruplex structure and is believed to play a major role in the regulation of bcl-2 transcription. However, an extensive functional exploration requires further investigation. To further exploit the structure-function relati...
متن کاملErratum: General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter
This is a correction to the following paper: General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter, Bo Liu, Da Li* and Hong Shang*, Chemistry Central Journal 2014, 8:43 (1 July 2014). CorrectionThis is a correction to the following paper: Generalperoxidase activity of a parallel G-quadruplex-h...
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عنوان ژورنال:
- Chemical communications
دوره 48 67 شماره
صفحات -
تاریخ انتشار 2012